The Hu Lab

Bioinformatics and Statistical Genetics


We thank the following organizations for generously funding our research projects.



Featured NSERC CREATE Graduate Training Program in Visual and Automated Disease Analytics (VADA)

We are looking for graduate students with computer science and / or (bio)statistics background to join the program

2017 May – 2023 Apr   

Title: Visual and Automated Disease Analytics (VADA)

Funding agency: NSERC, Collaborative Research and Training Experience (CREATE) Program

Principal Investigator: IRANI, Pourang
Co-Investigators: LIX, Lisa; BORYCKI, Elizabeth; KUSHNIRUK, Andre; ARINO, Julien; HU, Pingzhao; THOMO, Alex;

TZANETAKIS, George; van DOMESELAAR, Gary; KOBAYASHI, Karen, LEBOE-MCGOWAN, Jason


2020 Feb – 2025 Jan         
Title: Identification of novel antibiotic molecules by chemogenetic analysis and machine learning 
Funding agency: Canada Institutes of Health Research (CIHR), Project Grant Fall 2019                             
Principal Investigator: CARDONA, Silvia
Co-Investigators: HU, Pingzhao; DAVIS, Rebecca


2020 Jan – 2023 Dec          

Title: Prediction and prevention of rheumatoid arthritis in First Nations people
Funding agency: CIHR, Team grant: human immunology Initiative: Research Teams
Principal Investigator: El-GABALAWY, Hani
Co-Principal Investigator: WILKINS, John; MOOKHERJEE, Neeloffer; PESCHKEN, Christine
Co-Investigators: MARSHALL, Aaron; HU, Pingzhao; ANAPARTI, Venkata Veda Vidyanand; LAVOIE, Josee; MACKAY, Dylan; O'NEIL, Liam; ROBINSON, David; TANNER, Stacy; WOODS, Amanda; DUNCAN, Florence; BALLANTYNE, Friederike                        


2019 Sep – 2024 Aug         

Title: EpiGen marks for human sepsis
Funding agency: Canada Institutes of Health Research (CIHR), Project Grant Spring 2019
Principal Investigator: dos SANTOS, Claudia
Co-Investigators: HU, Pingzhao; BINNIE, Alexandra; CASTELO-BRANCO, Pedro; EVANS, David; MARSHALL, John; WALLEY, Keith; WEI, Xu 


2018 Aug – 2023 Jul  
Title: Role of taste signaling and host-microbial interactions on caries risk in young children

Funding agency: Canada Institutes of Health Research (CIHR), Project Grant Spring 2018

Principal Investigator: CHELIKANI, Prashen; SCHROTH, Robert

Co-Investigators: HU, Pingzhao; DUAN, Kangmin


2020 May – 2023 Apr     

Title: Epigenetic PowerBlade: DNA Precision Marks for Critical Illness
Funding agency: CIHR, 2019 Collaborative Health Research Projects (NSERC partnered)
Principal Investigator: dos SANTOS, Claudia; FOX-ROBICHAUD, Alison; VERES, Teodor;

Co-Investigators: BRASSARD, Daniel; GEISSLER, Matthias; HU, Pingzhao; MALIC, Lidija; MARSHALL, John; WALLEY, Keith


2018 Nov – 2020 Oct          

Title: Antibiotic discovery for Burkholderia cepacia complex 
Funding agency: Cystic Fibrosis Foundation (CFF), USA, Pilot and Feasibility Awards – Spring Cycle                              

Principal Investigator: CARDONA, Silvia
Co-Investigators: HU, Pingzhao; DAVIS, Rebecca



Principal Investigator


2020 Jul – 2023 June     
Title: Artificial Intelligence and Genomics-Driven Precision Oncology for Breast Cancer
Funding agency: Manitoba Medical Service Foundation Allen Rouse Basic Science Career Development Award,
Manitoba Medical Service Foundation and University of Manitoba
Principal Investigator: HU, Pingzhao


2020 Feb – 2023 Mar     

Title: The Terry G. Falconer Memorial Rh Institute Foundation Emerging Researcher Award
Funding agency: The Winnipeg Rh Institute Foundation and University of Manitoba
Principal Investigator: HU, Pingzhao


2020 Feb – 2022 Jan     
Title: Computational drug repurposing for Alzheimer's disease
Funding agency: University Collaborative Research Program (UCRP), University of Manitoba
Principal Investigator: HU, Pingzhao
Co-Investigators: KONG, Jiming


2019 Apr – 2022 Mar          

Title: Finding novel antibiotics against Burkholderia cepacia complex by genome-wide fitness and machine learning
Funding agency: Cystic Fibrosis Canada, Basic and Clinical Research Grants
Principal Investigator: CARDONA, Silvia
Co- Principal Investigators: HU, Pingzhao; DAVIS, Rebecca

2015 Apr – 2021 Mar   

Title: Developing novel machine learning algorithms for network Biology
Funding agency: Natural Sciences and Engineering Research Council of Canada, Discovery Grant
Principal Investigator: HU, Pingzhao


2020 Jan – 2021 Dec   
Title:
Deep learning for prioritizing small molecule candidates for drug repositioning
Funding agency: Natural Sciences and Engineering Research Council of Canada, Engage Grant
Principal Investigator: HU, Pingzhao


2017 Oct – 2019 Sep  

Title: Genome-wide diet-gene interaction analysis for risk of psychiatric comorbidity in inflammatory bowel disease
Funding agency: The Western Canadian Universities, Collaborative Project Seed Funding
Principal Investigators: Hu, Pingzhao
Co-Investigators: Charles Bernstein, Longhai Li, Linglong Kong, Svetlana Frenkel


2018 Jun – 2019 Jul            
Title: Identification of genomic signatures associated with MRI-based deep radiomic phenotypes of breast cancer tumors
Funding agency: Dr. Paul H.T. Thorlakson Foundation
Principal Investigator: HU, Pingzhao


2017 Jun – 2020 May   
Title: Exploring association between host genetics and microbiome in pediatric Crohn’s disease
Funding agency: Children’s Hospital Research Institute of Manitoba, Operating Grant
Principal Investigator: HU, Pingzhao
Co-Investigator: EI-MATARY, Wael; BERNSTEIN, Charles

2017 May – 2021 Apr   
Title: Developing novel machine learning algorithms for network Biology
Funding agency: Graduate Enhancement of Tri-council Stipends (GETS) Program, University of Manitoba
Principal Investigator:
HU, Pingzhao


2018 Jun - 2019 Feb
Title: Machine learning-guided development of multiscale imaging probes for colorectal cancer                        
Funding agency: New York Academy of Sciences and Japan Agency for Medical Research and Development
Principal Investigators: MURAKAMI, Kazuhiro; JUNKER, Anna; HU, Pingzhao

2015 Sep – 2018 Aug  

Title: Improving breast cancer survival and drug response prediction based on mutated gene network
Funding agency: Canadian Breast Cancer Foundation – Prairies/NWT Region, Research Grants
Principal Investigator: HU, Pingzhao


2017 Feb – 2018 Feb
Title: Genomics-based computational drug repositioning for inflammatory bowel disease
Funding agency: University of Manitoba,
University Research Grants Program (URGP)
Principal Investigator: HU, Pingzhao


2016 Sep – 2017 Dec  

Title: Identification of copy number variation biomarkers in patients with inflammatory bowel disease
Funding agency: Mitacs, Accelerate Program
Principal Investigator: HU, Pingzhao

Co-Principal Investigator: BERNSTEIN, Charles

2015 Sep – 2017 Aug  
Title: Identification of risk genes that modulate the severity of inflammatory bowel disease through copy number variation analysis
Funding agency: Health Sciences Centre Foundation (HSCF), General Operating Grants
Principal Investigator: HU, Pingzhao
Co-Principal Investigator: BERNSTEIN, Charles
Co-Investigators: SPRIGGS, Beth

 
2014 Aug – 2017 Jul  
Title: Bioinformatics Approaches for Integrative Analysis of Omics Data for Translational and Personalized Medicine
Funding agency: Manitoba Research Health Council, Establishment Grant
Principal Investigator: HU, Pingzhao
 
     
2016 Jun – 2017 Mar   
Title: Identifying disease genes and modeling their regulatory mechanism corresponding to inflammatory bowel disease
Funding agency: Nara Institute of Science and Technology (Japan), Global Collaboration Project FY2016
Principal Investigator (Japan): Md. Altaf-Ul-Amin
Co-Investigator (Japan): SATO, Tetsuo
Co-Principal Investigator (Canada): HU, Pingzhao


2014 Feb – 2017 Feb
Funding agency: University of Manitoba, Research Start-up Fund
Principal Investigator: HU, Pingzhao


2015 Apr – 2016 Mar
Title: Patient-specific pathway activations inferred from genomic data predict breast cancer survival
Funding agency: Manitoba Medical Service Foundation (MMSF), Operating Grant
Principal Investigator: HU, Pingzhao



2015 Feb – 2016 Feb
Title: Machine learning techniques for identifying pathway biomarkers
Funding agency: Faculty of Science and Faculty of Health Sciences, University of Manitoba
"Interdisciplinary / New Directions Research Collaboration Initiation" Program 
Principal Investigator: WANG, Yang
Co-Principal Investigator: HU, Pingzhao

2015 Jan – 2016 Jan
Title: A gene-pair based enrichment testing approach for identifying pathway biomarkers in cancer studies
Funding agency: University of Manitoba, University Research Grants Program (URGP)
Principal Investigator: HU, Pingzhao

Co-Investigator


2020 Jan – 2020 Dec     
Title: Harnessing Population-Based Electronic Healthcare Records to Construct Family Health Histories for Accurate Disease Risk
         Prediction and Heritability Estimation
Funding agency: Rady Faculty of Health Sciences, 2020 Rady Innovation Fund
Principal Investigator: LIX, Lisa
Co-Investigators: HU, Pingzhao; DELANEY, Joseph; JOZANI, Mohammad Jafari; WALL-WIELER, Elizabeth; BANERJI, Shantanu


2019 June – 2020 May  
 
     
Title: Prediction antibiotic activity from compound shape with machine learning
Funding agency: University of Manitoba, University Research Grants Program (URGP)
Principal Investigator: SILVIA, Cardona
Co-Principal Investigators: HU, Pingzhao; DAVIS, Rebecca

2017 Apr – 2019 Mar          
Title: Manitoba Statistical and Health Sciences (MB-SAHS) Collaborating Centre
Funding agency: Canadian Statistical Sciences Institutes
Principal Investigator: LIX, Lisa
Co-Investigators: ACAR, Elif; HU, Pingzhao; JAZARI, Mohammad Jofani; TORABI, Mahmoud


2017 Feb – 2019 Feb  
        
Title: Prediction of novelty and mode of action of natural antibacterial compounds by machine learning.
Funding agency: University of Manitoba, University Collaborative Research Program (UCRP).
Principal Investigator: SILVIA, Cardona
Co-Investigators: HU, Pingzhao; DAVIS, Rebecca

 
2016 Jul – 2017 Jun   

Title: Epigenetic mechanisms and association with septo-optic dyslplasia: a pilot project

Funding agency: Children’s Hospital Research Institute of Manitoba, DEVOTION – Catalyst Grant
Principal Investigator: RODD, Celia; WICKLOW, Brandy
Co-Investigators: MHANNI; Aziz; HU, Pingzhao


2015 May – 2016 Apr   

Title: Epigenetic profiling in severe sepsis – (EPSIS)
Funding agency: McLaughlin Centre, University of Toronto, Accelerator grant in genomic medicine
Principal Investigator: DOS SANTOS, Claudia
Co-Investigators: TSANG, Jennifer; BINNIE Alexandra; LIAW Patricia; HU, Pingzhao; CASTELO-BRANCO, Pedro


2015 Apr – 2016 Mar  

Title: Immunogenetic markers of extreme clinical phenotypes of post-transplant lymphoproliferative disorder: a pilot project.
Funding agency: Enduring Hearts Inc., USA, Operating Grant
Principal Investigator: ALLEN, Upton           
Co-Investigators: DIPCHAND, Anne; NG, Vicky; HU, Pingzhao; BEYENE, Joseph; PREIKSAITIS, Jutta; GRUNEBAUM, Eyal; LEVINGS Megan

2014 Jul – 2016 Jun   
Title: Deciphering DNA methylome in metastatic prostate cancer Funding agency: Prostate Cancer Canada, Movember Discovery Grants
Principal Investigator: BAPAT, Bharati
Co-Investigators: JOSHUA, Anthony; FLESHNER, Neil; BADER, Gary; HU, Pingzhao

2014 May – 2015 May
Title: Early detection of lung cancer using next generation sequencing technology Funding agency: McLaughlin Centre of University of Toronto, Accelerator grant in genomic medicine
Principal Investigator: LIU, Geoffrey
Co-principal Investigators: XU, Wei
Co-Investigators: HUNG, Rayjean; HU, Pingzhao